Alternative splicing in the 5′ moiety of the H-2Kd gene transcript.
Open Access
- 1 October 1984
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 3 (10), 2383-2386
- https://doi.org/10.1002/j.1460-2075.1984.tb02143.x
Abstract
The H‐2Kd gene, which encodes a mouse major transplantation antigen, was transfected into L TK‐ mouse fibroblasts. Two transcripts of the gene were detected by S1 nuclease mapping analysis. They correspond to two previously characterized cDNA clones isolated from DBA/2 mouse liver RNA, leading to the conclusion that the H‐2Kd gene gives rise to two distinct transcripts through an alternate use of splicing sites. The non‐canonical RNA potentially encodes a so far undescribed H‐2Kd‐like molecule. It is present in all tissues tested (liver, spleen, thymus, kidney) albeit in lower amounts (approximately 10‐fold less) than the canonical RNA coding for H‐2Kd.This publication has 31 references indexed in Scilit:
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