ECMO for Meconium Aspiration Syndrome: Support for Relaxed Entry Criteria
- 1 July 2007
- journal article
- research article
- Published by Wolters Kluwer Health in Asaio Journal
- Vol. 53 (4), 489-491
- https://doi.org/10.1097/mat.0b013e318063c602
Abstract
We compared the morbidity of patients with meconium aspiration syndrome (MAS) with that in patients with all other respiratory conditions treated with extracorporeal membrane oxygenation (ECMO) (no MAS). If ECMO for MAS was associated with a lower complication rate, then relaxed ECMO entry criteria could be considered. A retrospective review was performed of all patients in the national extracorporeal life support (ELSO) registry from 1989 to 2004. Complications were divided into mechanical, hematologic, neurologic, renal, pulmonary, cardiovascular, infectious, and metabolic categories. MAS and no-MAS patients were divided into veno-venous (VV) or veno-arterial (VA) ECMO categories, based on mode of ECMO used, and number of complications per patient in each category was determined. Statistical significance was determined by Chi-square test. A total of 1587 patients (700 MAS, 887 no MAS) on VV ECMO and 2723 (572 MAS, 2151 no MAS) on VA ECMO were identified with a total of 2415 complications in MAS and 9550 in no-MAS patients. Overall, MAS patients had a significantly lower number of complications per patient in each category versus no-MAS patients. These results indicate that regardless of type of ECMO, there are fewer complications on ECMO in MAS versus no-MAS patients. These data support the consideration of relaxed ECMO entry criteria for MAS.Keywords
This publication has 8 references indexed in Scilit:
- ECMO for neonatal respiratory failureSeminars in Perinatology, 2005
- Controversies in the treatment of meconium aspiration syndromeClinics in Perinatology, 2004
- Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatricsCritical Care Medicine, 2002
- Delayed institution of extracorporeal membrane oxygenation is associated with increased mortality rate and prolonged hospital stayJournal of Pediatric Surgery, 2002
- Advances in the treatment of the meconium aspiration syndromeActa Paediatrica, 2001
- Decreased Use of Neonatal Extracorporeal Membrane Oxygenation (ECMO): How New Treatment Modalities Have Affected ECMO UtilizationPediatrics, 2000
- Prospective, randomized comparison of high-frequency oscillation and conventional ventilation in candidates for extracorporeal membrane oxygenationThe Journal of Pediatrics, 1994
- Extracorporeal membrane oxygenation and neonatal respiratory failure: Experience from the extracorporeal life support organizationJournal of Pediatric Surgery, 1991