HIV-1 Vpr Loads Uracil DNA Glycosylase-2 onto DCAF1, a Substrate Recognition Subunit of a Cullin 4A-RING E3 Ubiquitin Ligase for Proteasome-dependent Degradation
Open Access
- 1 November 2010
- journal article
- Published by Elsevier in Journal of Biological Chemistry
- Vol. 285 (48), 37333-37341
- https://doi.org/10.1074/jbc.m110.133181
Abstract
No abstract availableKeywords
This publication has 79 references indexed in Scilit:
- A promiscuous α-helical motif anchors viral hijackers and substrate receptors to the CUL4–DDB1 ubiquitin ligase machineryNature Structural & Molecular Biology, 2009
- HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domainProceedings of the National Academy of Sciences, 2009
- Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcriptionNucleic Acids Research, 2009
- Human Immunodeficiency Virus Type 1 Vpr Binds to the N Lobe of the Wee1 Kinase Domain and Enhances Kinase Activity for Cdc2Journal of Virology, 2008
- HIV-1 Vpr: Mechanisms of G2 arrest and apoptosisExperimental and Molecular Pathology, 2008
- DDB1 and Cul4A Are Required for Human Immunodeficiency Virus Type 1 Vpr-Induced G 2 ArrestJournal of Virology, 2007
- Lentiviral Vpr usurps Cul4–DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycleProceedings of the National Academy of Sciences, 2007
- Human Immunodeficiency Virus Type 1 cDNAs Produced in the Presence of APOBEC3G Exhibit Defects in Plus-Strand DNA Transfer and IntegrationJournal of Virology, 2007
- HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1Proceedings of the National Academy of Sciences, 2007
- Function and regulation of cullin–RING ubiquitin ligasesNature Reviews Molecular Cell Biology, 2005