THE AUSTRALIAN REFERENCE PREPARATION OF HUMAN SERUM IMMUNOGLOBULINS

Abstract

An Australian Reference Preparation of human serum immunoglobulins was prepared from pooled sera of 240 healthy, adult donors. The preparation was calibrated for IgG, IgA and IgM levels by radial immunodiffusion against the 1st International Reference Preparation of Human Serum Immunoglobulins G, A and M (IgG, IgA and IgM) and for IgE by PRIST against the 1 st International Reference Preparation of Human Serum Immunoglobulin E (IgE). The following potency values were assigned to the Australian Reference Preparation designated ASPS 78-1 (Lyoph.): 100 IU/vial for IgG and IgE, 102 IU/vial for IgA and 114 IU/vial for IgM.