Crystal structure of myotoxin-11: a myotoxic phospholipase A2 - homologue from bothrops moojenivenom

Abstract

The crystal structure ofMyotoxin-II (MjTX-II), a Lys49 PLAi-homologue from Bothrops moojeni venom has been determined and refined at 2.0 A to a crystallographic residual of 19.7% (Ru.0=28.1%). MjTX-II is a dimer in the crystal, with the monomers in the asymmetric unit related by a two-fold symmetry axis running through the dimer interface. The dimers of MjTX-II and the Lys49 PLA2 from B. asper venom are similar, however the relative orientations of the monomers suggests a flexible dimer interface, which serves as a hinge between the two molecules.