The medical importance of anticholinesterase agents has become increasingly apparent in recent years, and organic phosphate compounds have been widely publicized as "G agents" or "nerve gases." Their potential use as chemical warfare agents against military or civilian populations makes it important that the medical profession become better acquainted with the diagnosis and treatment of anticholinesterase intoxication.1The organic phosphates are also among the most powerful and versatile insecticides developed to date, and extensive agricultural use has resulted in many accidental exposures and deaths. Cases of poisoning have occurred in workers and in adult and children nonworkers who have come into contact with these substances. Most cases reported in the literature have been due to ignorance or improper handling of the insecticide. The substantial number of severe cases brings organic phosphate poisoning into the province of all practitioners. TREATMENT OF ANTICHOLINESTERASE POISONING At the present time the best known