Signaling pathways in Th2 development
- 11 November 2004
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 202 (1), 203-222
- https://doi.org/10.1111/j.0105-2896.2004.00209.x
Abstract
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.Keywords
This publication has 282 references indexed in Scilit:
- Arginine Methylation of NIP45 Modulates Cytokine Gene Expression in Effector T LymphocytesMolecular Cell, 2004
- Immune Regulation by helminth parasites: cellular and molecular mechanismsNature Reviews Immunology, 2003
- A SLAT in the Th2 SignalosomeImmunity, 2003
- Magnetic relaxation switches capable of sensing molecular interactionsNature Biotechnology, 2002
- The immunobiology of schistosomiasisNature Reviews Immunology, 2002
- NFAT SignalingCell, 2002
- The other side of the coin: The protective role of the TH2 cytokinesJournal of Allergy and Clinical Immunology, 2001
- The biology of Stat4 and Stat6Oncogene, 2000
- Transcription factor GATA-3 is required for development of the T-cell lineageNature, 1996
- Disruption of the murine IL-4 gene blocks Th2 cytokine responsesNature, 1993