Effect of Free Fatty Acids on Renal Metabolism of Very Low Density Lipoprotein Triglyceride
- 1 January 1985
- journal article
- research article
- Published by S. Karger AG in Kidney and Blood Pressure Research
- Vol. 8 (1), 1-7
- https://doi.org/10.1159/000173028
Abstract
Metabolism of very low density lipoprotein-triglyceride (VLDL-TG) was studied in the isolated perfused rat kidney (IPRK). Recirculating perfusate consisted of KrebsHenseleit bicarbonate buffer containing 6% defatted albumin and VLDL-TG which has been labelled in vitro with 14C-tripalmitin. Results show that the IPRK catabolizes VLDL-TG. Renal removal of VLDL-TG from perfusate was impaired in the presence of 1.0 mM palmitate. A lower palmitate concentration, 0.4 mM, was without effect. It is concluded that high concentrations of circulating free fatty acids impair renal metabolism of fatty acids derived from VLDL-TG.Keywords
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