Spontaneous and Ultraviolet-induced Mutation in Escherichia coli: Interaction Between Plasmid and tif-1 Mutator Effects
- 1 July 1977
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 101 (1), 163-166
- https://doi.org/10.1099/00221287-101-1-163
Abstract
In E. coli, thermally-induced expression of the tif-I mutation causes enhancement of spontaneous and UV-induced mutagenesis. The effects of both plasmid expression and tif-I expression are recA+ dependent. The interaction between the plasmid and tif-I effects were examined to decide whether or not they act through the same mechanism. Analyses of variance showed that the joint effects of the plasmid pkM101 and tif-I are greater than additive, indicating that they affect separate steps in the same pathway of mutagenesis.This publication has 3 references indexed in Scilit:
- Ultraviolet light protection, enhancement of ultraviolet light mutagenesis, and mutator effect of plasmid R46 in Salmonella typhimuriumJournal of Bacteriology, 1976
- Expression of the plasmid pKM101-determined DNA repair system in recA − and lex − strains of Escherichia coliMolecular Genetics and Genomics, 1976
- Increase in frequency of ultraviolet-induced mutation brought about by the colicine factor, colI in Salmonella typhimuriumMutation Research, 1966