Hematogenous Pyelonephritis in Rats. II. Production of Chronic Pyelonephritis by Escherichia coli.

Abstract

Chronic bilateral pyelonephritis without manifest hydronephrosis was produced experimentally in the albino rat by a simple nonsurgical technique. This experimental disease provides a model for study of human pyelonephritis. Renal inflammation tended to persist after infection had disappeared. Vascular disease and hypertension did not develop; however, the lesions were of insufficient severity to produce azotemia.