Treatment of Local Anesthetic-Induced Cardiotoxicity Using Drug Scavenging Nanoparticles
- 3 March 2004
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 4 (4), 757-759
- https://doi.org/10.1021/nl049880w
Abstract
Because of its ability to create structures of nanoscale dimension with large aggregate particle surface area-to-volume ratios, nanotechnology offers new opportunities to treat drug poisonings. Emulsion-based nanoparticles (diameter: 118.4 nm) extracted bupivacaine from the aqueous phase in a physiological salt solution and attenuated the drug's cardiotoxicity in guinea pig heart to a greater extent than did a macroemulsion (432.0 nm). Additionally, nanoparticles sequestered bupivacaine from the aqueous phase of human blood and merit further investigation in animal models of intoxication.Keywords
This publication has 10 references indexed in Scilit:
- Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicityRegional Anesthesia & Pain Medicine, 2003
- Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac ToxicityRegional Anesthesia & Pain Medicine, 2003
- Mussel Adhesive Protein Mimetic Polymers for the Preparation of Nonfouling SurfacesJournal of the American Chemical Society, 2003
- Nanostructures as tailored biological probesTrends in Biotechnology, 2002
- Molecular imaging, targeted therapeutics, and nanoscienceJournal of Cellular Biochemistry, 2002
- Nanocapsule Technology: A ReviewCritical Reviews in Therapeutic Drug Carrier Systems, 2002
- Nanotechnology in bio/clinical analysisJournal of Chromatography B: Biomedical Sciences and Applications, 2000
- Pretreatment or Resuscitation with a Lipid Infusion Shifts the Dose-Response to Bupivacaine-induced Asystole in RatsAnesthesiology, 1998
- Triglyceride-Based Microemulsion for Intravenous Administration of Sparingly Soluble SubstancesJournal of Pharmaceutical Sciences, 1998
- Ionic Basis of the Differential Effects of Intravenous Anesthetics on Erythromycin-induced Prolongation of Ventricular Repolarization in the Guinea Pig HeartAnesthesiology, 1997