A Simple One-Pot Synthesis of Nitriles from Alcohols
- 1 April 1988
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 18 (4), 445-452
- https://doi.org/10.1080/00397918808064008
Abstract
Primary alcohols are cleanly converted into nitriles in excellent yields by a new, one-pot, two-step process, involving transformation into the corresponding trifluoroacetates followed by nucleophilic substitution reaction with sodium cyanide.Keywords
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