Studies on alloxan diabetes. 1. Increase of susceptibility caused by acetoacetate
- 1 February 1953
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 53 (3), 481-483
- https://doi.org/10.1042/bj0530481
Abstract
Rabbits injd. subcut. with 150 mg./kg. Na acetoacetate daily for 5 wks. show a slight rise in blood sugar, and an enormous fall in reduced glutathione in blood. The susceptibility of these treated animals to alloxan is greatly increased, 75 mg./kg. being the diabetogenic dose and 100 mg./kg. the lethal dose, as compared with 130-150 and 225 mg./kg., respectively, for controls.Keywords
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