Amino Acid Metabolism in McArdle's Syndrome

Abstract

RECENT studies in normal man have suggested a central role for alanine in the metabolism of resting and exercising muscle. It has been demonstrated that synthesis and release of alanine from muscle depend not only on catabolism of muscle protein but also on the rate of formation of pyruvate from glycolysis in muscle.^{1 , 2} Supporting this formulation is the direct linear correlation between arterial levels of alanine and pyruvate both at rest and during exercise,² and the finding that the augmented glycolysis induced by exercise is associated with a greatly increased output of alanine, proportional to the intensity of the work . . .