Roentgenograms of the vessels of the extremities injected with bismuth oxychloride after amputation indicate that the changes in the vessels leading to gangrene vary considerably. The differences in the collateral circulation indicate that different procedures may be employed to advantage in the treatment of some of these lesions, especially of thrombo-angiitis obliterans. Meleney and Miller,1in 1924, injected the vessels of the legs of Chinese, which had been amputated because of gangrene following a vascular lesion in every way similar to thrombo-angiitis obliterans observed in this country. Reichert, two years before this publication, had noted similar changes. His results were, however, not published. A roentgenogram of the injected vessels indicates the loss of the normal arrangement of the blood vessels, and in the main vessels patchy defects, indicating almost complete obliteration of the lumen of the vessel at some points. The most striking observation in these cases, which seems