The Enantioselective Step in the Nickel-Catalyzed Hydrocyanation of 1,3-Cyclohexadiene
- 15 August 2006
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (35), 11374-11375
- https://doi.org/10.1021/ja064378u
Abstract
On the basis of deuterium labeling experiments and an equal 1,2-/1,4-product distribution, the reductive elimination of the product has been established to be the enantioselective step in the nickel-catalyzed hydrocyanation of 1,3-cyclohexadiene. This could be achieved by successfully exploiting the rather unique features of this reaction: identical product formation for 1,2- and 1,4-addition, cis addition over the diene, and high enantiomeric excess.Keywords
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