Abstract
The activity of rosoxacin, fosfomycin, cefotiam and spectinomycin was measured against 51 isolates of .beta.-lactamase producing N. gonorrhoeae, all of which were susceptible to each drug at sufficient concentrations. The development of strains of penicillinase producing N. gonorrhoeae (PPNG) which are resistant to spectinomycin can therefore be avoided, as there are alternative drugs.