Untangling the signalling wires
- 1 March 2007
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 9 (3), 247-249
- https://doi.org/10.1038/ncb0307-247
Abstract
Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF–MEK–ERK cascade induced by two different growth factors. The study shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.Keywords
This publication has 18 references indexed in Scilit:
- Cell-signalling dynamics in time and spaceNature Reviews Molecular Cell Biology, 2006
- Long‐range signaling by phosphoprotein waves arising from bistability in protein kinase cascadesMolecular Systems Biology, 2006
- Causal Protein-Signaling Networks Derived from Multiparameter Single-Cell DataScience, 2005
- When kinases meet mathematics: the systems biology of MAPK signallingFEBS Letters, 2005
- Raf PhosphorylationMolecular Cell, 2005
- Inferring dynamic architecture of cellular networks using time series of gene expression, protein and metabolite dataBioinformatics, 2004
- A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and DurationMolecular and Cellular Biology, 2004
- Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1Nature, 2003
- Identification of the Mechanisms Regulating the Differential Activation of the MAPK Cascade by Epidermal Growth Factor and Nerve Growth Factor in PC12 CellsJournal of Biological Chemistry, 2001
- Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activationCell, 1995