In Vitro Demonstration of an Endothelial Proliferative Factor Produced by Neural Cell Lines
- 14 November 1975
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4215), 682-684
- https://doi.org/10.1126/science.171768
Abstract
Cultured endothelial cells exhibit a six- to tenfold increase in thymidine labeling index in response to a soluble factor elaborated by clonal cell lines of neural origin. This factor, endothelial proliferation factor, appears to be a unique property of tumor cells and may mediate the vascularization of these neoplasms.This publication has 8 references indexed in Scilit:
- Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIAJournal of Clinical Investigation, 1973
- TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATIONThe Journal of Experimental Medicine, 1972
- Tumor Angiogenesis: Therapeutic ImplicationsNew England Journal of Medicine, 1971
- ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESISThe Journal of Experimental Medicine, 1971
- ESTABLISHMENT OF FUNCTIONAL CLONAL LINES OF NEURONS FROM MOUSE NEUROBLASTOMAProceedings of the National Academy of Sciences, 1969
- Endothelial Mitosis around Aortic Branches in Normal Guinea-pigsNature, 1968
- Differentiated Rat Glial Cell Strain in Tissue CultureScience, 1968
- Vasculae Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic TransplantsJNCI Journal of the National Cancer Institute, 1945