The Microcirculation of Skeletal Muscle in Aging
- 1 June 2006
- journal article
- review article
- Published by Wiley in Microcirculation
- Vol. 13 (4), 275-277
- https://doi.org/10.1080/10739680600618710
Abstract
Microvascular structure and function are key aspects of tissue and organ health. At approximately 40% of total body mass, skeletal muscle contains more microvessels than any other organ system in the body. Moreover, skeletal muscle is the most dynamic tissue in the body with the capacity to increase blood flow and metabolic rate 30‐ to 50‐ fold. Aging is associated with decrements in microvascular function and exercise tolerance that are poorly understood. Here, experts in their respective fields of microvascular structure and function are brought together to review the current state of knowledge regarding microvascular adaptations to aging. Reviews are drawn from human and animal studies and focus on age‐related changes in sympathetic nervous system control of microvessels, capillary hemodynamics and oxygen pressure, microvascular network structure and functional integration, microvascular reactivity, whole muscle perfusion, and cellular contacts and inflammation.Keywords
This publication has 18 references indexed in Scilit:
- Vasodilation and Vascular Control in Contracting Muscle of the Aging HumanMicrocirculation, 2006
- α‐Adrenergic Control of Skeletal Muscle Circulation at Rest and During Exercise in Aging HumansMicrocirculation, 2006
- Effect of Inflammation on the Aging Microcirculation: Impact on Skeletal Muscle Blood Flow ControlMicrocirculation, 2006
- Aging‐Induced Adaptations of Microvascular ReactivityMicrocirculation, 2006
- Effect of Aging on the Structure and Function of Skeletal Muscle Microvascular NetworksMicrocirculation, 2006
- Accelerated Longitudinal Decline of Aerobic Capacity in Healthy Older AdultsCirculation, 2005
- An Obligation for Primary Care Physicians to Prescribe Physical Activity to Sedentary Patients to Reduce the Risk of Chronic Health ConditionsMayo Clinic Proceedings, 2002
- Muscularity in adult humans: Proportion of adipose tissue‐free body mass as skeletal muscleAmerican Journal of Human Biology, 2001
- Human Cardiovascular ControlMedicine & Science in Sports & Exercise, 1993
- Maximal perfusion of skeletal muscle in man.The Journal of Physiology, 1985