THE PATHOGENESIS OF PROTEINURIA IN THE ACUTELY CONGESTED KIDNEY 1

Abstract
In an experimental study of the pathogenesis of proteinuria in the acutely congested kidney of the anesthetized dog, it was found that: Proteinuria appeared frequently following acute elevation of the renal venous pressure to levels of 250 mm of water or higher; Proteinuria occurred within 1 hour following elevation of the renal venous pressure in most animals, and disappeared promptly upon lowering the venous pressure to control levels; Proteinuria appeared to be due to the rise in venous pressure and independent of changes in renal blood flow.