Effects of 4‐aminopyridine on Statistical Parameters of Transmitter Release at the Neuromuscular Junction

Abstract

4-Aminopyridine (4-AP) potentiates transmitter release from motor nerve terminals [rat extensor digitorum longus muscle and frog (Rana temporaria) sartorius muscle] by increasing the quantum content (m) of endplate potentials [epp]. Estimates of the binomial parameters of transmitter release shows that 4-AP enhances m by increasing n [the store of transmitter available for release] and not p [the probability of release of available transmitter quanta].