The effect of phalloidin on insulin secretion from islets of langerhans isolated from rat pancreas
- 1 October 1984
- journal article
- Published by Wiley in FEBS Letters
- Vol. 175 (2), 393-396
- https://doi.org/10.1016/0014-5793(84)80775-9
Abstract
Phalloidin, which stabilizes F‐actin, has no effect on insulin secretion from intact islets, but penetrates and increases secretion from islets previously made permeable using a high voltage discharge technique. Use of this highly specific drug strongly suggests a role for microfilaments composed of F‐actin in the insulin secretory process.Keywords
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