GROWTH HORMONE RESPONSE TO PROSTAGLANDIN E2
- 1 May 1979
- journal article
- research article
- Published by Wiley in Acta Paediatrica
- Vol. 68 (3), 251-256
- https://doi.org/10.1111/j.1651-2227.1979.tb04997.x
Abstract
C[cyclic]AMP causes release of growth hormone [GH] from the pituitary. Prostaglandin [PG] increases pituitary adenylate cyclase and cAMP and therefore acts as a GH-releasing hormone. Using PGE2 (30 .mu.g/k body wt) given i.v. there was no growth hormone response to insulin hypoglycemia when PGE2 failed to evoke a response. In 6 of 18 patients unresponsive to insulin hypoglycemia a significant rise in GH was obtained from PGE2. In these 6 patients hypothalamic unresponsiveness to hypoglycemia must be operative whereas PGE2 acting directly at pituitary level is likely to have caused the release of preformed GH from the pituitary. Administration of PGE2 does not cause hypoglycemia but rather a slight rise in the plasma glucose level. The risk of brain damage which is inherent in the insulin hypoglycemia test is avoided.Keywords
This publication has 9 references indexed in Scilit:
- CLINICAL USE OF GLYCINE INTRAVENOUS LOAD FOR DIAGNOSIS OF GROWTH HORMONE DEFICIENCYClinical Endocrinology, 1976
- Evaluation of growth hormone release in children using arginine and l-dopa in combinationThe Journal of Pediatrics, 1975
- A Review of Growth Hormone Stimulation Tests in ChildrenPediatrics, 1974
- Prostaglandin-induced premature oviposition in the coturnix quailProstaglandins, 1972
- Studies on growth hormone secretion: IV. In vivo effects of prostaglandin E1Prostaglandins, 1972
- EFFECT OF PROSTAGLANDIN ON THE SECRETION OF HUMAN GROWTH HORMONEJournal of Clinical Endocrinology & Metabolism, 1971
- Release of Pituitary Growth Hormone by Prostaglandins and Dibutyryl Adenosine Cyclic 3′:5′-Monophosphate in the Absence of Protein SynthesisProceedings of the National Academy of Sciences, 1970
- STIMULATION OF ANTERIOR PITUITARY ADENYL CYCLASE ACTIVITY AND ADENOSINE 3′:5′-CYCLIC PHOSPHATE BY HYPOTHALAMIC EXTRACT AND PROSTAGLANDIN E 1Proceedings of the National Academy of Sciences, 1969
- Role of Cyclic 3′,5′-Adenosine Monophosphate in the Release of Growth Hormone in vitroNature, 1967