A DOUBLE-BLIND CONTROLLED CLINICAL-TRIAL OF FLUOXETINE AND AMITRIPTYLINE IN THE TREATMENT OF OUTPATIENTS WITH MAJOR DEPRESSIVE DISORDER
- 1 January 1985
- journal article
- research article
- Vol. 46 (3), 32-37
Abstract
Fluoxetine, a specific serotonin reuptake inhibitor, was compared to amitriptyline in the treatment of 51 outpatients with primary major depressive disorder. After a 1-wk placebo washout, patients were randomly assigned to 5 wk of treatment with fluoxetine or amitriptyline. Fluoxetine had a therapeutic effect comparable to that of amitriptyline; the fluoxetine treatment group had a better Efficacy Index-side Effects rating and a lower incidence of anticholinergic autonomic side effects. Four amitriptyline-treated patients had to discontinue the study because of serious side effects, while in the fluoxetine treatment group there were no terminations due to side effects. The amitriptyline-treated patients gained significantly more weight than the fluoxetine-treated patients.This publication has 6 references indexed in Scilit:
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