Guanosine Triphosphate Activation of Brain Adenylate Cyclase: Enhancement by Long-Term Antidepressant Treatment
- 7 January 1983
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4580), 65-67
- https://doi.org/10.1126/science.6849117
Abstract
Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock. These treatments may facilitate cyclase activation by promoting the interaction of the regulatory and catalytic subunits of the enzyme. This finding suggests a possible mechanism for the changes in sensitivity to various neurotransmitters seen after antidepressant administration.Keywords
This publication has 29 references indexed in Scilit:
- Chronic antidepressant treatment enhances α-adrenergic and serotonergic responses in the facial nucleusLife Sciences, 1980
- Biochemical Properties of Hormone-Sensitive Adenylate CyclaseAnnual Review of Biochemistry, 1980
- Swedes vote on their nuclear futureNature, 1980
- Adrenergic Subsensitivity of a Cell‐free Adenylate Cyclase from Rat Brain after Chronic Imipramine TreatmentArchiv der Pharmazie, 1980
- The effect of repeated administration of antidepressant drugs on the responsiveness of rats to catecholamine agonistsJournal of Neural Transmission, 1979
- Inhibition of platelet adenylate cyclase by epinephrine requires GTPFEBS Letters, 1978
- Development of β-adrenergic receptor subsensitivity by antidepressantsNature, 1977
- Influence of injected psychoactive drugs on cyclic amp levels in mouse brain and lung following microwave irradiationNeuropharmacology, 1977
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry, 1976
- REGIONAL STUDIES OF CATECHOLAMINES IN THE RAT BRAIN‐IJournal of Neurochemistry, 1966