BIOSYNTHETIC INCORPORATION OF ONE-CARBON UNITS INTO BERBERINE AND HYDRASTINE

Abstract
The utilization of one-carbon precursors in the biosynthesis of hydrastine and berberine was investigated by tracer experiments with plants of Hydrastis canadensis L. The lactone group of hydrastine and the bridge carbon of berberine are shown to be derived from the S-methyl group of methionine.

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