The relative infrequency of lesions of the adrenal glands becomes apparent when one examines statistical surveys of necropsies. In all probability this accounts for the slight attention given such lesions in the past. Increasing interest in the endocrine glands during recent years, however, has greatly stimulated the study of pathologic changes in the adrenal glands. It is often difficult to establish the presence of lesions of the adrenal glands in the living patient; the symptoms and signs may be indefinite compared to the extent of the lesion observed at autopsy. Again, symptoms referable to the adrenal glands may be obscured by those of a more acute and fulminating disease. During the past six years, in the course of performing routine necropsies, we have collected 39 instances demonstrating pathologic changes in these organs. In view of the fact that knowledge of these glands still remains incomplete, the clinical and pathologic observations