Catabolism of Glucose and Gluconate in Intact Rats

Abstract

When glucose is administered to intact rats per os, it is catabolized mainly by way of the EMP pathway. Some of the administered glucose was also routed into the phosphogluconate decarboxylation and glucuronate decarboxylation pathways. Gluconate can be readily utilized by intact rats via the phosphogluconate decarboxylation pathway. The pentose phosphate so formed is believed to be converted to F-6-P which in turn is further catabolized primarily by way of the EMP route.