Diabetes Insipidus Associated with Edema

Abstract

Diabetes insipidus, a syndrome characterized by polyuria, polydipsia and excretion of urine of low specific gravity, may result from a deficiency of the neurohypophyseal antidiuretic hormone.¹ Since this hormone is presumed to control the "facultative" reabsorption of water in the distal tubule of the kidney the specific physiologic "defect" in diabetes insipidus is usually attributed to a decrease or absence of renal reabsorption of water in this portion of the nephron.² As a consequence of this physiologic abnormality, the untreated patient with diabetes insipidus may suffer from dehydration resulting from loss of water in excess of intake, unless he is . . .