Effects of aspirin on platelet aggregation as a function of dosage and time

Abstract

There are reports on the effects of high doses of aspirin on the alteration of platelet aggregation. In the study single doses of aspirin ranging from 81-325 mg were given orally to 7 normal [human] subjects. In vitro measurement of platelet aggregation was performed as a function of time. Based on the data, low-dose aspirin (81 mg) inhibits platelet aggregation. Both the rate and extent of platelet aggregation are impaired with low-dose aspirin, but the rate or extent of platelet aggregation did not depend on the size of the dose. Platelet aggregation inhibition by a single dose of aspirin orally (.gtoreq. 81 mg) may be expected to persist for the life of the platelets affected.