Effects of somatostatin on ethanol-induced gastric erosions in the rat: Role of mast cells
- 1 April 1986
- journal article
- Published by Springer Nature in Inflammation Research
- Vol. 18 (1-2), 273-275
- https://doi.org/10.1007/bf01988040
Abstract
Somatostatin (S) inhibits hemorrhagic gastric erosions produced by ethanol. In this study we compared the dose-dependent effects of linear (reduced) and cyclic (oxidized) S with respect to mast cell degranulation. The gastric mucosal injuries were more inhibited by linear S than by cyclic S. But linear S aggravated injury at a certain dose (10−7 mol/rat). Mucosal mast cell degranulation correlated significantly with the area of hemorrhagic mucosal lesions (r=0.91). Both cytoprotection as well as aggravation potency of S may be connected to gastric mucosal mast cell activity in the rat.Keywords
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