Linkage group HL-A-MLC-Bf (properdin factor B)
- 1 January 1975
- journal article
- Published by Springer Nature in Human Genetics
- Vol. 27 (3), 173-183
- https://doi.org/10.1007/bf00278344
Abstract
Genetic linkage between the HL-A and Bf loci could be confirmed in 43 families with 168 offspring. In 4 families, 5 recombinants out of 82 informative meiotic divisions were observed (r=6.1%). The localisation of the Bf marker system was studied in 3 families with crossovers between HL-A and MLC. From these data the following map order of human chromosome 6 can be proposed: HL-A (1st locus) —HL-A (2nd locus)—MLC-Bf---PGM3. The fact that important components of the classical and alternate pathway of complement activation are governed by genes closely linked with HL-A and MLC loci leads to the proposition to include the Bf system into the Major Histocompatibility Complex in man.Keywords
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