INTESTINAL ABSORPTION OF AMINO ACIDS

Abstract

The rate of L-histidine transfer from mucosa to serosa of everted rat intestine was inhibited by diphosphopyridine nucleotide which was restored to the original level by pyridoxal phosphate. L-Methionine absorption through intestine wall determined by perfusion technique in situ was suppressed by L-penicillamine but not by the D-isomer. Pyridoxal phosphate group of tryptophanase and trans-aminase preparations was bound by both L- and D-penicillamines to form the thiazolindine compounds, though only the L-isomer was inhibitory on those enzymes.