Herpesvirus saimiri: Protective effect of attenuated strain against lymphoma induction

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Abstract
An attenuated strain of Herpesvirus saimiri (A-HVS) induced a persistent, latent infection in common marmosets. Virus was recovered from circulating lymphocytes of infected animals and antibody response to virus-specified antigens was demonstrated over 3-12 mo. A-HVS-infected common marmosets and animals without previous A-HVS exposure were challenged with oncogenic HVS (125-825 PFU [plaque forming unit]). Marmosets without A-HVS infection developed malignant lymphoproliferative disease and died 3 wk later whereas all persistently-infected animals have survived 38-43 mo. post challenge.