How bacterial protein toxins enter cells: the role of partial unfolding in membrane translocation
- 1 November 1992
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 6 (22), 3277-3282
- https://doi.org/10.1111/j.1365-2958.1992.tb02195.x
Abstract
Bacterial protein toxins translocate across membranes by processes that are still mysterious. Studies on diphtheria toxin have shown that partial unfolding processes play a major role in toxin membrane insertion and translocation. Similar unfolding behaviour is seen with other bacterial toxins. The lessons gained from this behaviour allow us to propose novel mechanisms for toxin translocation.Keywords
This publication has 34 references indexed in Scilit:
- Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursorCell, 1992
- Diphtheria toxin: membrane interaction and membrane translocationBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1992
- Inositol 1,4,5-triphosphate directly opens diptheria toxin channelsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1991
- ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding proteinCell, 1991
- The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformationNature, 1991
- Folding changes in membrane-inserted diphtheria toxin that may play important roles in its translocationBiochemistry, 1991
- On the nature of the structural change of the colicin E1 channel peptide necessary for its translocation-competent stateBiochemistry, 1990
- Membrane permeability to macromolecules mediated by the membrane attack complexBiochemistry, 1989
- Lipid interaction of diphtheria toxin and mutants with altered fragment BEuropean Journal of Biochemistry, 1987
- Secondary structure and assembly mechanism of an oligomeric channel proteinBiochemistry, 1985