Intestinal Alkaline Phosphatase in Human Serum

Abstract

Normal human sera containing electrophoretically slow-moving alkaline phosphatase, are more susceptible to L-phenylalanine and to anti-human intestinal alkaline phosphatase antibody than human sera not containing this slow-moving component. A good correlation exists in individual sera between phenylalanine sensitivity and antibody sensitivity. These findings constitute further evidence that slow-moving alkaline phosphate is of intestinal origin. In sera containing intestinal alkaline phosphate this enzyme accounts for approximately 20% of the total alkaline phosphatase activity.