Preinvasive carcinoma of the cornea and conjunctiva.

Abstract
Grayish-white spots, varying in size, caused diagnostic problems in 2 patients with preinvasive corneal carcinoma. Keratectomy specimens permitting light microscopy and EM indicated that the smaller spots predominating in 1 patient correlated with epithelial microscysts and vacuoles, while areas of parakeratosis accounted for the macroscopic white patches found in the other. A variety of ultrastructural abnormalities, including excessive basement membrane fibrillogenesis, were present in both cases.