Critical Role of Adrenal Glands in Precocious Increase in Jejunal Sucrase Activity Following Premature Weaning in Rats: Negligible Effect of Food Intake
- 1 January 1980
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 110 (1), 169-177
- https://doi.org/10.1093/jn/110.1.169
Abstract
The effect on jejunal sucrase activity of premature weaning (PW) of rats is studied and compared with the effect of starvation. Within 24 hours after PW of rats on postnatal day 16 onto a high sucrose diet, there is a highly significant increase in sucrase activity as compared with that in nonseparated controls. During this time, food intake is minimal, the rats lose weight and there is an arrest of jejunal growth. Rats starved from day 16 onward exhibit the same increase of sucrase activity. Adrenalectomy on day 14, i.e. 2 days before PW, results in 33% mortality on the second postweaning day, i.e. on day 18, and in progressive loss of jejunal protein. Sucrase activity in adrenalectomized prematurely-weaned rats does not differ from the activity of intact suckling controls on day 18. Our experiments suggest that the increase in sucrase activity following PW is not related to food intake, but is primarily mediated by the adrenal glands. Presented results stress the importance of the endocrine system in the intestinal “adaptive” response to PW in the rat. Endocrine factors should be considered in any evaluation of the effect of nutritional manipulation during the weaning period.Keywords
This publication has 20 references indexed in Scilit:
- Comparison of the Effect of Various Doses of Thyroxine on Jejunal Disaccharidases in Intact and Adrenalectomized Rats during the First 3 Weeks of LifeEnzyme, 1978
- EFFECT OF THYROIDECTOMY ON THE ACTIVITY OF α-GLUCOSIDASES AND ACID HYDROLASES IN THE SMALL INTESTINE OF RATS DURING WEANINGJournal of Endocrinology, 1975
- Studies on Normal and Precocious Appearance of Jejunal Sucrase in Suckling RatsNeonatology, 1975
- Effect of carbohydrate and corticosteroids on activity of α-glucosidases in intestine of the infant ratJCI Insight, 1972
- Cell migration and cortisone induction of sucrase activity in jejunum and ileumBiochemical Journal, 1972
- Postnatal Development of the Small Intestine of the Rat: Changes in Mucosal Morphology at WeaningPediatric Research, 1969
- Effect of Diet upon Intestinal Disaccharidases and Disaccharide Absorption*JCI Insight, 1967
- THE METABOLISM OF LIPIDS DURING POSTNATAL DEVELOPMENTPublished by Elsevier ,1966
- Intestinal Invertase: Precocious Development of Activity after Injection of HydrocortisoneScience, 1964
- Studies of small intestine during development I. Distribution and activity of ß-galactosidaseBiochimica et Biophysica Acta, 1962