mar Operon Involved in Multidrug Resistance of Enterobacter aerogenes
- 1 April 2002
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (4), 1093-1097
- https://doi.org/10.1128/aac.46.4.1093-1097.2002
Abstract
We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.Keywords
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