Asymptomatic striatal dopamine depletion: PET scans in unilateral MPTP monkeys
- 1 January 1988
- Vol. 2 (5), 469-473
- https://doi.org/10.1002/syn.890020502
Abstract
In cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MRTP) produces irreversible clinical, chemical, and pathological alterations that are similar to those found in Parkinson's disease. Unilateral carotid injections of this toxin produce ipsilateral nigrostriatal dopamine depletion while sparing the contralateral dopaminergic pathways. In order to study the damage to the nigrostriatal dopamine system in asymptomatic animals after unilateral MPTP administration, positron emission tomography (PET) scans were performed with [18F]fluoro-L-dopa (6-FD). This study demonstrates that clinically asymptomatic MPTP lesions may be assessed in vivo using 6-FD and PET.Keywords
This publication has 14 references indexed in Scilit:
- Evidence for neuromelanin involvement in MPTP-induced neurotoxicityNature, 1987
- Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeysAnnals of Neurology, 1986
- Chronic treatment withl-DOPA, but not bromocriptine induces dyskinesia in MPTP-parkinsonian monkeys. Correlation with [3H]spiperone bindingBrain Research, 1986
- Hemiparkinsonism in monkeys after unilateral internal carotid artery artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)Life Sciences, 1986
- Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleusNeuroscience Letters, 1985
- Positron emission tomography after MPTP: observations relating to the cause of Parkinson's diseaseNature, 1985
- Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.Proceedings of the National Academy of Sciences, 1985
- Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitorsNature, 1984
- Central Dopaminergic Pathways in Hemiparkinsonism Examined by Positron Emission TomographyCanadian Journal of Neurological Sciences, 1984
- A new autoradiographic approach for imaging forebrain dopamine distributionAnnals of Neurology, 1982