Long‐term in vivo studies of poly(2‐hydroxyethyl methacrylate)
- 13 September 1982
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 16 (5), 609-617
- https://doi.org/10.1002/jbm.820160508
Abstract
Poly(hydroxyethyl methacrylate) (PHEMA) was implanted subcutaneously in rats, hamsters, and guinea pigs for up to 24, 23, and 13 months, respectively. The tissue response and tumorigenesis caused by PHEMA were compared among the three species of the animals. Thick fibrous capsule formation and tumor production were noted only in rats, while no tumorigenesis and thin fibrous capsule formation were observed in hamsters and guinea pigs. These results support our previous hypothesis that animals producing a thick and avascular capsule tend to develop tumors at the implant site. PHEMA retrieved was characterized by scanning electron microscopy and x‐ray energy dispersive analysis. Calcium and phosphorus were the main elements detected on the surface of PHEMA implants. PHEMA is suggested to be not suitable for long‐term implant material.This publication has 10 references indexed in Scilit:
- The use of 99Tc‐pyrophosphate for imaging and measuring of calcification caused by implanted polymersJournal of Biomedical Materials Research, 1980
- Role of cell shape in growth controlNature, 1978
- Analysis of biomaterials deposited on soft contact lensesJournal of Biomedical Materials Research, 1977
- Calcification and Bone Induction Studies in Heterogeneous Phosphorylated HydrogelsPublished by American Chemical Society (ACS) ,1976
- Hydrogels for Medical and Related ApplicationsACS Symposium Series, 1976
- An ultrastructural study of the biocompatibility of poly(2-hydroxyethyl methacrylate) in boneJournal of Biomedical Materials Research, 1975
- Biological tolerance of ionogenic hydrophilic gelsJournal of Biomedical Materials Research, 1973
- Effect of porosity of heterogeneous poly(glycol monomethacrylate) gels on the healing‐in of test implantsJournal of Biomedical Materials Research, 1971
- Use of spongy hydron in plastic surgeryJournal of Biomedical Materials Research, 1968
- Carcinogenesis Through Solid State Surfaces*Published by S. Karger AG ,1963