EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMY

Abstract

Cholesterol metabolism in renal diseases has been reviewed by Cantarow¹and by Page and his associates.²The probable significance of phospholipids and their relation to free cholesterol have been discussed by Sinclair.³It is well known that there is an increased concentration of plasma cholesterol in nephrosis and in the nephrotic types of glomerulonephritis. There appears to be no logical explanation for the changes in the cholesterol values of the blood in these diseases. There has been little work concerning lipid metabolism of experimental animals with renal insufficiency to compare with results obtained for patients with impaired renal function. It is the purpose of this investigation to study the plasma cholesterol and lipid phosphorus values for partially nephrectomized and control rats fed diets containing varying concentrations of dried extracted liver. The operative procedure for unilateral and partial nephrectomy, the methods for estimating blood pressure and renal function