Pathological gambling is linked to reduced activation of the mesolimbic reward system
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- 9 January 2005
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 8 (2), 147-148
- https://doi.org/10.1038/nn1378
Abstract
By analogy to drug dependence, it has been speculated that the underlying pathology in pathological gambling is a reduction in the sensitivity of the reward system. Studying pathological gamblers and controls during a guessing game using functional magnetic resonance imaging, we observed a reduction of ventral striatal and ventromedial prefrontal activation in the pathological gamblers that was negatively correlated with gambling severity, linking hypoactivation of these areas to disease severity.Keywords
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