The structure of crotonitenone, a novel casbane diterpene from Croton nitens Sw. (Euphorbiaceae)
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 2666-2669
- https://doi.org/10.1039/p19810002666
Abstract
A novel casbane diterpene, crotonitenone {(E)-(1R*,5S*,7R*,11S*,14S*)-5-hydroxy-3,7,11,15,15-pentamethylbicyclo[12.1.0]pentadec-2-ene-4,8-dione}(7), C20H32O3, has been isolated from Croton nitens(Euphorbiaceae) and its structure and relative stereochemistry have been established by chemical, spectral, and X-ray crystallographic means. Crystals of (7) are monoclinic, space group P21, with a= 12.446(1), b= 13.285(1), c= 5.872(1)Å, β= 97.02(1)°, and Z= 2. The structure was refined by least squares to R 0.040 and R′ 0.038.This publication has 2 references indexed in Scilit:
- Total synthesis of the macrocyclic diterpene (–)-casbene, the putative biogenetic precursor of lathyrane, tigliane, ingenane, and related terpenoid structuresJournal of the Chemical Society, Perkin Transactions 1, 1980
- Tumor inhibitors. 111. Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitorJournal of the American Chemical Society, 1976