Results of a Clinical Investigation of Clotrimazole (Canesten), A New Anti-Mycotic Substance, in the Therapy of Vaginal Fungal Infections

Abstract

In an open controlled trial, 100 patients with vaginitis were treated with clotrimazole vaginal tablets. Ninety-four patients were infected with Candida and six patients with trichomonas. Therapy was continued for six days in 80% of patients and for up to twelve days in 18%. Judged on clinical and mycological results at the end of therapy, 57 patients were cured and 25 patients improved (90·1% effective). No patients were made worse and side-effects were minimal. The trial showed that clotrimazole was a fast, safe and effective treatment for candida vaginitis. Insufficient patients had trichomonas vaginitis for a clear conclusion to be drawn.