The Ehlers-Cohn-Danlos1 syndrome was until recently considered uncommon in America. Tobias2 reported the first case in the United States in 1934. In the last few years cases have been reported with increasing frequency. The syndrome is characterized by excessive fragility of the skin and the blood vessels, hyperelasticity of the skin, hyperflexibility of the joints and the formation of pseudotumors and subcutaneous nodules. REPORT OF A CASE A. R., a white boy aged 3 years, was admitted to the pediatric ward of the Brooklyn Jewish Hospital, with the complaint of excessive bruising and bleeding. The family history was irrelevant. The child was born prematurely, in the thirty-second week of gestation, and weighed only 2½ pounds (1.15 Kg.) at birth. It was necessary to give him two transfusions of blood for weakness and cyanosis. His development was then normal. He had a cervical abscess when he was 1 year