THE RELATIONSHIP OF THE BLOOD BRAIN BARRIER OF THE RAT TO I131-LABELLED TRIIODOTHYRONINE
- 1 December 1959
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Nervous & Mental Disease
- Vol. 129 (6), 530-541
- https://doi.org/10.1097/00005053-195912000-00002
Abstract
The entry of triiodothyronine (T3) into the brain of the rat does not seem to be markedly delayed in comparison with its entry into skeletal muscle when the hormone reaches the brain through its normal vascular channels. Some of the T3, which enters the brain, reaches the cerebrospinal fluid, possibly by diffusion across the ependymal or pial-glial membranes. This shift from brain to cerebrospinal fluid appears unidirectional since I131-labelled T3 injected into the cerebrospinal fluid failed to penetrate these membranes.Keywords
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