Meleney's1recent review of histoplasmosis (Darling) listed 32 cases. Since his review 2 more cases of the disease have been reported by Brown, Havens and Magath2and by Rhodes, Conant and Glesne.3Another case, in which a patient recently admitted to St. Luke's Hospital for the diagnosis and treatment of a chronic lesion of the larynx was found to have the Histoplasma capsulatum infection, is reported here. The tissues in the lesion of the larynx had the specific structure seen in histoplasmosis. The mold was cultured from specimens taken for biopsy. Intradermal injections of filtrates of broth cultures of the fungus in the patient and in animals experimentally infected caused immediate and delayed specific cutaneous reactions. REPORT OF CASE A white man aged 63 had irritation of the throat and hoarseness for eighteen months, pain in the left side of his throat for seven months and a