In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to IS Aba1 -Mediated Overexpression of the Natural bla OXA-66 Oxacillinase Gene
- 1 June 2009
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 53 (6), 2657-2659
- https://doi.org/10.1128/aac.01663-08
Abstract
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the IS Aba1 element upstream of the naturally occurring bla OXA-66 carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla OXA-66 gene.Keywords
This publication has 15 references indexed in Scilit:
- Functional Analysis of Insertion Sequence IS Aba1 , Responsible for Genomic Plasticity of Acinetobacter baumanniiJournal of Bacteriology, 2009
- Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiologyClinical Microbiology & Infection, 2006
- The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumanniiFEMS Microbiology Letters, 2006
- Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumanniiClinical Microbiology & Infection, 2006
- Characterization of the Naturally Occurring Oxacillinase ofAcinetobacter baumanniiAntimicrobial Agents and Chemotherapy, 2005
- Contribution of Acquired Carbapenem-Hydrolyzing Oxacillinases to Carbapenem Resistance in Acinetobacter baumanniiAntimicrobial Agents and Chemotherapy, 2005
- Emergence of Plasmid-Mediated Quinolone Resistance in Escherichia coli in EuropeAntimicrobial Agents and Chemotherapy, 2005
- OXA-58, a Novel Class D β-Lactamase Involved in Resistance to Carbapenems inAcinetobacter baumanniiAntimicrobial Agents and Chemotherapy, 2005
- Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumanniiJournal of Antimicrobial Chemotherapy, 2004
- Outbreak of Extended-Spectrum β-Lactamase VEB-1-Producing Isolates of Acinetobacter baumannii in a French HospitalJournal of Clinical Microbiology, 2003